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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 14.85
Human Site: S1023 Identified Species: 29.7
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 S1023 D T E G K S P S H S S S N R P
Chimpanzee Pan troglodytes XP_001172395 1581 168474 S1023 D T E G K S P S H S S S N R P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 S1025 E G K S P S H S S S N R P F T
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 S1025 E G K S P S H S S S N R P F T
Rat Rattus norvegicus NP_001127833 1567 166392 H1009 T E G K S P S H S S N R P F T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589
Chicken Gallus gallus XP_418125 1594 169410 S1034 D G K S P S H S S S N R P F T
Frog Xenopus laevis Q6INP8 1570 165663 I1014 D G K S P S H I T N R P F T P
Zebra Danio Brachydanio rerio XP_700209 1694 176982 S1081 E P D A K S P S H S A G G R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 P946 F A S V G A P P P P P P I P P
Honey Bee Apis mellifera XP_395879 1811 193227 T1249 P A S K K P P T Q T S P K L S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 N1469 L I H A P N K N V S S P T T G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 20 N.A. 20 6.6 N.A. 0 26.6 20 53.3 N.A. 13.3 20 N.A. 13.3
P-Site Similarity: 100 100 N.A. 40 N.A. 40 13.3 N.A. 0 40 33.3 73.3 N.A. 20 33.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 17 0 9 0 0 0 0 9 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 34 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 25 9 17 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 9 0 0 0 0 0 0 0 0 0 0 0 9 34 0 % F
% Gly: 0 34 9 17 9 0 0 0 0 0 0 9 9 0 9 % G
% His: 0 0 9 0 0 0 34 9 25 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 9 0 0 0 0 9 0 0 % I
% Lys: 0 0 34 17 34 0 9 0 0 0 0 0 9 0 0 % K
% Leu: 9 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 0 9 0 9 34 0 17 0 0 % N
% Pro: 9 9 0 0 42 17 42 9 9 9 9 34 34 9 42 % P
% Gln: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 9 34 0 25 0 % R
% Ser: 0 0 17 34 9 59 9 50 34 67 34 17 0 0 9 % S
% Thr: 9 17 0 0 0 0 0 9 9 9 0 0 9 17 34 % T
% Val: 0 0 0 9 0 0 0 0 9 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _